Seminiferous tubule and testicular degeneration and atrophy were reported in male mice receiving intraperitoneal (IP) doses of 3 mg/kg/day (9 mg/m2/day, approximately 17% of clinical recommended dose on a mg/m2 basis).
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Biological risk factors for BPD include a family history of this diagnosis, substance abuse, antisocial personality disorder, impulsivity, or mood instability.
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After an intravenous bolus dose, the steady state of volume distribution [mean (%cv)] is 302.9 (32%) liters.
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BREVIBLOC concentrations were equivocally higher when given with warfarin, but this is not likely to be clinically important. |
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